PROLOGUE

After working in the Emergency Department (ED) for more than fourteen years, I cannot count the number of abdominal pains, chest pains, broken bones, lacerations, heart attacks, strokes, MVCs, stabbings, and gunshots I encountered. I also saw patients in anaphylaxis, which is when an acute allergic reaction leads to swelling of the airway, tongue, lips, and face so that a person’s ability to breathe is compromised. Sometimes a relative rolled them in the door, the patient arching back in a wheelchair as they took their last gasp. But, there actually weren’t that many of them. I can count them, just like the number of cases of priapism (an erect penis that just won’t stop being erect!), or foreign objects mysteriously lodged in a rectum (you can scarcely imagine). I would put the number of anaphylaxis patients over fourteen years at…twenty.

You might then understand that when six of my patients at the Leading Edge Clinic have either approached anaphylaxis or come within a minute of dying from the same, over the short period of six months, well, it got my attention.

What is going on here? To give you an answer, we’ll have to go back in time a few years.

RECENT PAST

 

In my Substack Honest Fight I wrote about my 2019 trip to Sweden and Norway with Ellen David Friedman, a veteran union organizer and international labor leader. While we were there, we spent most of our time with teachers, but had a visit with dockworkers, and also met some nurses and doctors. I had a fascinating one-on-one meeting with Anne Lindgren Berndt, President of Vårdförbundet. Also known as the Swedish Association of Health Professionals, Vårdförbundet is the trade union and professional organization of four registered professions; nurses, midwives, biomedical scientists and radiographers. It represents more than 80 % of the workforce.

During our conversation, Anne shared a story which stuns me to this day. A young couple made a trip to the countryside outside of Stockholm for a picnic with their two young children. After a bee stung their not-yet-one-year-old daughter, her lips began to swell and her breathing turned raspy. They called emergency services and within ten minutes a helicopter with an emergency nurse and physician landed in a nearby clearing. They administered a lifesaving epinephrine injection, and within minutes the girl was breathing more easily. Then they bundled up the girl and flew off to the nearest hospital right? Nope. The pilot, nurse, and doctor hung out for more than thirty minutes, monitoring the little girl, getting a health history, providing a pair of epi-pens, providing education about how and when to use the pens, and ensuring that there would be a followup the next day with her pediatrician. Then they returned to their helicopter and flew away, leaving the young family to enjoy the rest of their picnic. True story.

Sweden is not nirvana, or Ellen and I wouldn’t have been there meeting with union members across several sectors. The neocons strategically, methodically, almost invisibly, have hollowed out the strength and influence of Swedish labor over a period of decades. And still, the story above demonstrates what is possible when a country dedicates more than a fraction of its resources to rational healthcare instead of endless wars.

PAST

Dr Lawrence Afrin is considered by many to be the expert on mast cell activation (MCAS) in the United States, and Dr Gerhard Molderings his equivalent in the United Kingdom. An aside—would you agree that someone with the last name Molderings sounds like he should be in a Harry Potter movie? Anyway, in 2016, Afrin, Molderings et. al. wrote a review of how to treat MCAS. It was titled Pharmacological treatment options for mast cell activation disease. If I could wave a magic wand and bring the medical establishment up-to-date on the post-Covidian world, I would make these twenty three pages of clinical wisdom required reading. But seeing as how this isn’t a Harry Potter movie, and I misplaced my magic wand, I’m going to write you dear readers and try to arm you with some potentially lifesaving information.

The meat of the article lays out a step-wise approach to treating MCAS. Some of these therapies should be familiar by now to most patients with post-acute sequelae of Covid (PASC) and injury from the Covid shots: H1 and H2 anti-histamines, Cromolyn, Ketotifen, etc. What evaded my attention for months, but which rose in prominence with each successive instance of anaphylaxis, was Table 12.

 

As I pay tribute to Dr Afrin, I also feel compelled to share some small insight into the complexity of this man’s mind and expertise. When a hero fails to live up to the expectations in one’s mind, does it make a sound? For me, it sounds kind of like a “whumpf.” It turns out that “whumpf” has been adopted as technical avalanche term, which describes the sound made when a heavier lay of snow collapses under the weight of a person or machine walking over a lighter/weaker layer of snow, sometimes preceding an avalanche. Sounds auspicious to me! So, Dr Afrin has been a hero of mine, shedding light on the topic of MCAS through his prolific writing on the topic. My “whumpf” moment came when a patient told a provider in our practice that a nurse in Dr Afrin’s practice said he believes in the safety and efficacy of the Covid shots, and thinks that Paxlovid is an effective first-line treatment for acute Covid. In case that was hearsay, I checked with another colleague who has been in regular communication with Dr Afrin, and she/he said, “Yup, that’s about right.” If the poignancy of this is lost on you, give it time.

PRESENT

The origin of mast cells helps explain why hyperactivation in MCAS is so problematic. When life on this planet leapt from single to two-celled organisms, mast cells were the second cell to arrive. They were the original bouncers of life, and tasked with protecting the organism. They developed a wide repertoire of tools, which included mediators. We can count the birth, life and death of a platelet or white blood cell in about a week. Red blood cells last up to two months. Mast cells last—get this—two to four years! How would you like to really, really, really piss off your mother-in-law, and then find out she was moving in with you for the next four years? No bueno.

When a person is exposed to the spike protein, whether from infection, shedding, or vaccination, the spike protein hyperactivates the mast cells. In a person who didn’t have mast cell disease before the pandemic, this may not have significant consequences. But in a person who had some degree of mast cell disease before Covid, this can be disastrous. These are people who may have had environmental allergies, food sensitivities, rashes, unexplained headaches, irritable bowel disease, asthma, etc.

So what are mediators? They are substances released by mast cells with characteristics that promote, manage and resolve our immune response, particularly in allergic and inflammatory processes that lead to healing. When they spin out of control, or stay around too long, they cause lots of trouble. E.g. cytokines. Remember all the people who died during the pandemic in the winter of 2021 from cytokine storm? Those cytokines were coming from mast cells. What other mediators are there? Histamines, heparin, proteases, leukotrienes and prostaglandins.

 

Back to Table 12. I’ll skip down to local anesthetics, because I think this point touches the largest number of people. Procaine is what most of us know as Novacaine. It’s the most commonly used local anesthetic in dentistry, because of it’s rapid onset and short duration. In post-Covidian times, in mast cell activated patients, there is a big downside to Novacaine—it can provoke release of mediators from mast cells. If you’re a person without any history of MCAS, perhaps this is no big deal. But what if you are limping along with PASC or vaccine injury?

One of my patients is in his mid-30s, and vaccine injured. He needed to have some involved dental work, and rather than it taking a day or two to recover, it took eight to nine days. A few days after this, he went out to eat with his family and at ate some elk meat. Before the meal was over, he was starting to have trouble breathing, and his throat felt like it was closing. He had an old epi-pen in the glove compartment of his vehicle, and used it. His family drove him to the nearest ED, and he lost consciousness on the way due to diminished breathing and lack of oxygenated blood flow to his brain. He literally came within minutes of losing his life.

Why did this happen? If we go back to the period after he received the Covid shots, one conclusion of the exhaustive testing by system doctors who couldn’t find any abnormal tests, or almost none, was that he had Alpha-gal Syndrome. Ever heard of it? Me neither. It’s a potentially life threatening condition which can occur after a tick bite, and results in a delayed allergic reaction to mammalian meat. Mammals have tits and nurse their young, so we’re talking about the four-leggeds, such as pigs, cows, sheep, but also deer, rabbits, and elk. The likelihood of developing Alpha-gal are pretty slim, or at least they used to be, with estimates as low as 1-2% of the pediatric and adult population. Having never encountered it during thirty years of practice, I’ve now encountered it twice in the last year in our practice.

The patient had experienced some difficulty breathing and throat scratchiness after diagnosis with Alpha-gal, and before eating elk meat, enough to be cautious and have an Epi-pen, but what sent him over the edge? A dental procedure with Procaine, or Novacaine led to a close call.

 

Table 12 doesn’t just point out the dangers, it also points towards the solutions, or alternatives. In the case of Novacaine, there is the alternative of Bupivacaine. This is a local anesthetic which takes longer to numb tissue, up to fifteen minutes, and lasts longer, up to eight hours. That makes it a lot less convenient for dentists and patients, but most dentists will have it on hand. It just requires some advanced planning and communication.

It’s worth noting that Lidocaine is on the naughty list too. If you cut yourself badly and go to the local Urgent Care for some stitches, the chances are that the suturing physician will use Lidocaine to numb up the site first. It may be worth discussing your options.

If we go back up the list of Table 12, we’ll find SSRIs. This is the one instance where there literally is no alternative. Examples are citalopram, escitalopram, fluoxetine, fluvoxamine, and sertraline. And how many people take SSRIs? In the United States, about 13% of the adults or 43 million people. Worldwide, estimates suggests 4-5% of the global population or 300-400 million people. Hey, I’m sorry to put a damper on pharma profits, but I think that we’ve got a problem here. MCAS + SSRIs= mediator release → increased potential for anaphylaxis.

Moving back down the list, we find peripheral acting analgesics such as Aspirin and Ibuprofen. This is where I would caution the reader, and say, “Hey, let’s not go overboard here.” Any decision about whether to use or not use a therapeutic, at what dose, and for how long, is based upon a risk vs benefit decision. We can do this! Heck, most adults drive a car, and that is one non-stop rolling series of risk-benefit decisions. Ibuprofen? Well, if you’re well hydrated, and take it with food, and haven’t just eaten a high-histamine meal with avocado, leftovers, and alcohol (inhibits diamine oxidase or DAO, which breaks down histamine) then you could be fine. But what if you take an SSRI, and you just had dental work with Novacaine, and then you had a high histamine meal. Perhaps Tylenol might be a better choice, or rather least worst choice.

Next up on the list are some opiate analgesics, some of my favorites: morphine and codeine. Meperidine or Demerol is there too, but very rarely used these days.

Trying to quit smoking or fending off the blues with Wellbutrin / Bupropion? I’m sorry to say but that’s on the naughty list too.

How about antibiotics? Not to feel left out, we have some of those too, including Cefuroxime (I think there was a typo leaving the e off the end on the list) and Vancomycin. You’ll generally encounter these in the hospital setting via IV administration. Which is also where you’ll find iodinated contrast medium (think CT contrast) and gadolinium chelate (think MRI contrast). It is into this spiderweb of therapeutics that one of my patients recently landed, with serious adverse consequences.

This patient is in his eighties, and being treated with adjunctive cancer care for renal cell carcinoma which has metastasized to his lungs and bones. One of his arms swelled up to three times the size, and his wife took him to the ED. There was a turf war there, in which the Dermatologist opined that his arm was the biggest hive she had ever seen, and recommended antihistamine treatment (think MCAS). Oncology opined that he had cellulitis, brushed aside Dermatology’s recommendations, and ordered IV antibiotics with a cousin of Cefuroxime; these are antibiotics called Cephalosporins, commonly used to treat skin infections. They also ordered an MRI with contrast. Hours later, the patient was streaking down the hallway, trying to escape, exhibiting what would be called delirium, and powerfully pushing aside his wife in his rush. After being home for several days, she reports that his mind still isn’t the same, his sleep is disrupted, and “it has been rough.” So who was right, Dermatology or Oncology? I would vote Dermatology, and say that Oncology picked two therapeutics interventions, an IV Cephalosporin and an MRI with gadolinium chelate which both ramped up mediator release from his already hyperactive mast cells and created a pro-inflammatory and disruptive environment in his brain which contributed to delirium in this vulnerable, elderly patient.

How could mast cell mediators contribute to delirium? Cytokines such as TNF-alpha and IL-6 can cross the blood brain barrier and promote inflammation. Histamine increases blood brain barrier permeability, allowing inflammatory molecules and other immune cells to enter the brain, ramping up neuroinflammation and disregulating neuronal connections. Histamine can also directly bind to histamine receptors in the brain and impact neurotransmitter release and signaling, particularly with acetylcholine and dopamine, both strongly associated with delirium. Mediators can cause dilation and increased permeability of blood vessels in the brain which affect cerebral blood flow negatively. Mediators like proteases and reactive oxygen species can induce oxidative stress which can damage neurons and lead to cognitive dysfunction and delirium.

The therapeutics on the bottom of Table 12 are ACE inhibitors, such as Lisinopril, and beta blockers, such as Metoprolol. ACE inhibitors relax veins and arteries to lower blood pressure, and are often first-line therapies for hypertension due to concurrent protective impact upon kidney function. Beta blockers block the effect of the hormone and neurotransmitter epinephrine, causing the heart to beat less forcefully and more slowly. We can’t and shouldn’t throw the baby out with the bath water, understanding that patients are often on these medications for good reason, but also expanding our focus, and realizing that use of these medications in a post-Covidian era can prime an individual for a spillover of mast cell mediators, which could in some cases lease to anaphylaxis.

An example in this case is my patient who never had any allergies to seafood, but is on an ACE inhibitor for blood pressure, and takes LDN, Ketotifen, takes Antronex with meals, and as needed H1/H2 antihistamines for her MCAS. She went out to dinner with her husband and was in a restaurant which was sparsely populated, so less risk of shedding. She had a glass of wine (inhibits DAO production to break down histamine) and ordered seafood Alfredo, which had shrimp, scallops and clams. When she began eating her entree, it started to feel like her lips were swelling and her throat was tightening, but it wasn’t obvious to the dining companion observing her. She stopped eating the dish, and this sensation of throat tightness continued for more than twelve hours afterwards. When we discussed this during a followup visit, I suggested that we order her an Epi-pen, and reviewed Table 12 with, explaining that I think she was approaching an anaphylactic reaction.

 

A very important teaching around Epi-pens is that they come in pairs for a reason. Remember that the Swedish helicopter nurse and physician left a pair of epi-pens? Epinephrine is a short-acting medication, and its effects can wear off before a person reaches emergency medical providers. If the patient separated the pens, and put one in a car and one in their home for instance, they may have just one Epi-pen on hand in an emergency. That is what happened with my 30-something patient with Alpha-gal Syndrome, and without a second pen to administer, he nearly died before his family got him to the ED.

My final words of advice are to print out Table 12 and carry it with you. Discuss it with your PCP, dentist, surgeon and anesthesiologist. In a post-Covidian era, our bodies are different, and we need to be smart about how we may respond to drugs and agents which never troubled us before. Be prepared.

P.S. Thank you to Deb for her original artwork, the feature image of this Substack, a tribute to Pierre and I, and our work at the Leading Edge Clinic in treating PASC and injury from the Covid shots.

P.S.S. If you’ve ever heard the Beatles song Revolution 9 (you need to listen to it with a set of ear buds or headphones), you might appreciate why I wanted to call this Substack Table 12. It’s not a zinger of a title, but it should be, because Table 12 is so darned important. I hope that after reading this Substack you’ll agree.

PAST

I had pecked girls on the cheek when I was still in elementary school, but the first time I really kissed a girl, I was in eighth grade. I was attending RHAM Junior High School in rural Amston, CT where we lived on an oil and stone road, between woods and a swamp, . It was Christmas time, and there was a community gathering up the street. The party was in a house built in 1790, and had a stable in back — along with some real live horses. I was trying to disappear into the couch as I nibbled cookies and listened to the adults talking and laughing.

Suddeny this girl was standing in front of me, with a halo of Christmas tree light behind her like my very own angel of mercy. “Can I sit here?” Jesus, Joseph and Mary! “Uh, yeah, sure.” Awkward, so awkward, but somehow we started talking. Before too long, she asked if I had been out to the the stable. Shit, I didn’t even know there was a stable. “Nope.” “Do you want to check it out?” “Yup.”

As I write this forty two years later, it’s the first time it occurs to me that this was a girl who knew what she wanted and had a plan. She had long, shiny chestnut hair, and gold rimmed aviator glasses that made her look kind of like a young Farah Fawcett to me. How could I have never not noticed her before? Granted we didn’t ride the same bus, and we weren’t in the same classes, but we sure had some quick chemistry.

We talked for a long time that evening. I have no recollection what we talked about, but I do remember the novelty of having an extended conversation about a wide range of topics with a girl my age. I can recall the explosions in my brain that came from the kiss which she initiated next to the horse stables, but more than that, I was thunderstruck by what it felt like to be attracted to another human being, and have those feeling reciprocated.

There was something magical about the holiday music drifting from the house, the cold air and smells of the tack and straw, and the quiet sounds of the horses moving and breathing. It turned out that she was a horse girl, so this was her comfort zone. She had been riding horses since she was little, and this helped explain her predilection for plaid shirts and blue jeans. I made a mental note that horsey girls had a lot to offer until proven otherwise.

School was out for Christmas break, and since she lived just up the street, I called the number she had scribbled on a scrap of paper the night before. She picked up on the second ring, and yes, I could come by to hang out. She lived in one of the many saltbox houses that can be found on back country roads in New England. Her parents were both at work, and she had her own bedroom. Geese, I couldn’t hear what she was saying for my heart pounding in my ears. More kissing ensued.

Sadly, it didn’t last beyond the first day back at school. I remember looking up from my open locker to see her walking down the hall with some girlfriends. Our eyes met, and then she looked away, and that was that. Her mom answered the phone the next few times I tried to call. No explanation, no note, no nothing. The rejection stung, but I didn’t languish. I figured that her clique had passed judgement and I didn’t meet the bar. It sure was nice while it lasted….

LESS DISTANT PAST

In 1989 I was studying international business in Copenhagen, Denmark. The net effect of my efforts was to persuade me that I had chosen the wrong path, but I stuck with it in order to finish my degree in business economics rather than add a fifth year of classes and pile of debt to my college experience. It was around this time that I became very interested in farming, and set a long-term goal to acquire some practical knowledge on the subject.

 

If the Fall of 1993, I headed to south central France for an apprenticeship at Le Couteil, the farmstead of La Famille Carlier. The 120 acre farm raised organic meat, which was butchered on site and taken to regional farmers markets in a refrigerated truck unlike anything I’ve seen in the states. The farm house dated back to the 1700s and had been the poker retreat of a French duke.

My first assignment upon arrival was cleaning the leather collars for the draft horses. These horses were in fact double ponies called Haflingers, which hailed from the Swiss mountains. They are beautiful and intelligent creatures who are sturdier than horses and love to work. Fieldwork at Le Couteil, whether it was spreading manure, plowing, or harvesting hay, was done with the team hitched up four abreast or two and two, depending upon the task. There was also an enormous Percheron on the farm which was used more for pleasure riding in a carriage.

 

Cleaning out the cow stalls, bringing hay to the cows in the pasture, and generally working about the farm left me in the leanest, meanest state of physical strength I have been before or since. The biggest meal of the day was lunch, and Brigitte would create the most magnificent dishes from the simple pallette of eggs, farm cheese, leeks, potatoes, butter, onions and the range of meat and poultry grown on the farm. She would also make mouthwatering tarts from the apples kept in cold storage. Almost everything, including the wheat for the flour used to bake our bread, was grown on the farm.

The only dietary objection I had during my tenure with the Carliers was beef tongue, because I simply couldn’t get past the texture. Ultimately, I enjoyed the blood sausage (saucisson noir), but I needed at least a week’s distance from the blood-covered kitchen table and the site of the slaughtered pig’s head bobbing up and down in a huge stock pot on the stove!

 

This period of my life could and will serve as a rich repository of stories for Lightning Bug, as the learning was so deep and extensive. For now, I’ll say that I learned I was not meant to be a farmer, as the physicality of it left me with two shoulders burning and aching to such a degree that I couldn’t lift my arms to wash my face. Perhaps with better pacing I could make it work, but in the meantime, I pivoted to a career in healthcare and have been at it for more than thirty years. Even with the supports in place from the French government, and people willing to pay the equivalent of $10/lb for organic meat in 1994, the Carliers struggled. I could foresee the backbreaking work, debt and uncertainty that farming in the United States was likely to involve. There was a good nursing program at the Community College of Philadelphia which I could pay for as I worked my way through school. The pay wasn’t great, but the job security was appealing, and it would be a skillful way to serve humanity.

PRESENT

Long before we ever met, I watched Pierre’s testimony in front of the US Senate Subcommittee which eight million other people watched before You Tube took it down. My wife had called me into the living room with “Hey, you’ve got to see this!” Halfway through I was certain of several things: this guy had guts, he was smart, he was risking it all, and going to the mat for what he believed. Two previous conversations clicked into place like the tumblers on a combination lock to a safe holding the crown jewels. The first conversation had been with my cousin Danny, who follows the latest on solar flares and is a prepper. He had asked me if I ever heard of this drug called ivermectin and whether it could help treat COVID. I had arrogantly responded that I’d never heard of it, and because I worked in a unversity hospital with world renowned medical researchers, it must be a non-entity or we’d be using it. The second conversation was with my dentist, who had done black box research for the Department of Defense in a physiology lab at Temple University before his foray into dentistry. He asked me the same question as my cousin, except this time the source of the question got my attention. Then came Pierre’s fateful senate testimony.

The next day I was in the feed store at Agway with a $100 bill looking for horse paste. I found it and cleared an entire display of it off the shelf. The exchange between the clerk and I was hilarious, mostly non-verbal. She, in her worn flannel and Carharts, who could have easily bench-presseed three of me, her eyes saying “If you’re a horse owner, I’m Barbie.” Me, in my LL Bean fleece, Italian beanie, and Keen shoes, daring her with my eyes “That’s a Ben Franklin on the counter baby, and I mean business.”

My wife and I figured out that the 0.2mg/kg dose was easy-peasy, just dial in the syringe for our weight, give a little push, and a pea-sized dollop of titanium dioxide, propylene glycol, artificial green apple flavor, and ivermectin landed in the spoonful of applesauce. We toasted each other with a clink-clink of our spoons and down the hatch it went. Until the day we could get a human prescription, after paying $400 each for a consult with a telemedicine doc and $120 each for a prescription, it was weekly horse paste and applesauce for us. The worst thing that happened was eventually I developed some wicked heartburn.

I’d had two doses of our special applesauce before my first Pfizer. Yes, I know, I know, the unvaccinated in the crowd are shouting, “Why?!?” I didn’t know yet. I was terrified of dying. I was practically kissing COVID patients and spending two hours at a time sweating my tuckus off in a plastic gown, providing care in a 10ft by 10ft room.

There was one other colleague at work who was on the same page. We both started the horse paste at the same time. I rarely have contact with him now, as he has continued working at SUNY Upstate. It was helpful, though, to know and strategize with another nurse who had made the same calculations and decided that the risk-benefit ratio said to do it.

I used to be ashamed about taking the horse paste and wouldn’t have wanted to share this information. Today, knowing that both my wife and I are vaccine injured from bad batch shots: mine, Pfizers, and hers, Moderna, I am grateful that we did what we did. For my part, if I didn’t have two doses of IVM in my body before the first shot, I think I would be dead. What I understand today, which took a while to comprehend, is that it isn’t me or my wife who bear any shame. It is the physicians who went along with the system and endorsed untested and lethal shots for us who should be ashamed. We were just trying to survive.

Dr Paul Marik gave a brief interview after the recent news of the FDA settlement in the case he and two others brought against the agency for its “Ivermectin is for horses” campaign, and subsequent movement to block physicians from prescribing IVM to prevent and treat COVID. He said “This idea that ivermectin is a dangerous horse-deworming medicine is horse shit. I’m sorry to say that. It is nonsense. Millions of people on this planet have been treated with ivermectin. It is one of the safest medications…After penicillin, this is probably one of the most important medications ever developed by medical science.” Truth be told, Dr Marik, truth be told.

PAST

Those of you who have read my Substack since the beginning, may recall the story about me poking a stick in the yellow jackets nest. There were other more benign, but related events of me probing and testing the world and its inhabitants. In fact, there are many memorable non-events. Did escalators scare you as a child? Heck, did the bathtub drain scare you? I know it scared at least some of us, because Mr Rogers sang a song about it. “You Can Never Go Down the Drain.” Hah!

I wish he’d done a song about the sharp teeth of the escalators, but at least he did produce a sweet episode about up and down which included escalators. In my little kid brain, it seemed absolutely possible that my sneakers could get caught in moving stairs, pulled into them and mashed into bits! Every Christmas my wife and I watch Elf, with Will Ferrel, and I think the scene with him doing that fearful split on the ascending escalators is brilliant.

The escalators in our local Sears Roebuck were particularly captivating— and terrifying— to me as a child. One year around Christmas I saw the big red button at the base of the handle belt, with letters underneath that said STOP. Without much thought and zero premeditation I leaned over and pushed it. Then, those mashing metal teeth stopped. The silence was eerie. I felt this sensation of power over my destiny, that little old me could stop this enormous machine with the push of a button. I looked around and saw no one. Realizing that I maybe should not have done that, I hastily made my getaway. I ran down the now still stairway which released a hollow clunk with each step. I caught up with my mom and we left without further incident— until twelve years later….

SLIGHTLY MORE RECENT PAST

As a teenager, I lived with my Nana and Pop pop in the tiny village of Parkerford, PA, in a little house, with a corn field in our backyard.  My high school was named after the former Supreme Court Justice Owen J Roberts.  We had an active chapter of the Future Farmers of America (FFA), and in the Fall and Spring seasons, when the windows of our classrooms were open, the sweet smell of cow manure being spread on the fields filled the air.  There was also a farm store across the street from our school where many of us headed for snacks before catching the late bus home.  

Trips into the vast city of Philadelphia were therefore a very big deal.  My friend Larami, now an esteemed Interventional Neurologist in the University of Pennsylvania health care system, loved, loved, loved to initate those trips.  We would drive to Paoli and catch the R5 SEPTA Regional Rail line into Center City Philadelphia.  Before Christmas of 1986, Larami, his brother Monk , Chris and I made one such trip.  Larami’s inspirations and infatuations of the moment circumscribed our plans.  So, first we went for the buffet at Salad Alley in the Bourse Building for lunch. Then we headed to The Galleries for some shopping. This was an urban mall with at leat four levels opening onto a vast interior, and it…was…packed.  We entered on the street level and approached the escalator.  Without premeditation, and with an impulsivity that I cannot explain or defend, my eyes landed on the big red STOP button below the escalator railing, right where it had been all those years ago. I leaned over, and pushed it.

Unlike the Sears escalator of my boyhood however, this one was packed with people, who all gave a little forward and backward bobble as the escalator suddenly stopped.I was just ahead of my friends, and when they saw what I had done, they looked at me in surprise, perhaps amusement, and then concern. Within moments I was surrounded by at least six very large security officers. The Gallery didn’t mess around with security. Gang activity and drive by shootings were on the rise, and off-duty police officers could pick up some nice extra pay during Christmas. These security officers were at least twice as tall and three times as wide as me.

Their radios crackled. Ccckkkk “Level one escalator has stopped. Nobody appears to be hurt.” Ccccckkkkkk “We have a white male teen in custody.” Cccckkkkk. Before they even bothered asking me what I had done, they turned to my friends and asked “Is he with you?” They all shook their heads no and slowly backed away. F#@*?rs!! Obviously we were together. Then the guards all turned back to me. I remember looking up and seeing about five hundred people lining the railings of the different levels to see what was gong to happen to this crazy little white boy.

Time passed. I was contemplating what I would tell my Pop pop when I called from the city jail. “You what!?!” More radio crackling. Cccckkkkk “Yes sir. Yes sir. No sir. I don’t think so sir. Roger that sir.” Cccccckkkkk. One of the very big men looked at me and said “We’re going to have to ask you and your friends to leave and not return to the premises.” Really? That’s it? No jail? No report? They escorted me and my disavowing friends to the nearest exit and stood inside the doors to make sure we went on our way.

Well, dear reader, I’d be lying if I said that was the last button I ever pushed. Which brings me to the present moment.

PRESENT

Once a month I meet with wise man who I’ll call my business guru and emotional mentor. His name is Geep, and he likes to tell me instructive stories which I don’t always enjoy. One thing which he has told me more times than I can remember is, “Scott, try not to piss people off by accident.” Well, last week on the FLCCC Webinar, I think I pissed off a lot of women who are keen on using collagen to soften their wrinkles, harden their nails, and keep their hair from falling out. Frankly, I’m lucky to be alive!

It was great fun being on the weekly webinar with Dr Marik. During the webinar, when I shared my observations that collagen appeared to be provoking platelet aggregation and activaton in my patients, it didn’t seem like a big deal. Perhaps what I forgot to say was what all of the Tarot readers my wife watches on You Tube say: “The following is for entertainment purposes only.” When Pierre texts me on Saturday and writes “I known it’s your one day off, but….”, what follows is never good. It seems that I stirred up a shit storm with those observations and the FLCCC was trying to manage it.

To differentiate the players, the FLCCC is a rigorously science-based organization, and Dr Marik is the guardian of that galaxy. If there aren’t studies to back an assertion, or a heck of a lot of clinical observeration, it isn’t going to make it onto the FLCCC protocols. On the other hand, the Leading Edge Clinic is our private telemedicine practice, and as diligent clinicians, if we see signals that a therapy is harming our patients, we won’t wait until a study comes out to warn them. For example, Dr Peter McCullough asserted months ago that shedding wasn’t real, because he couldn’t find any studies which supported the ideas. The rest is history, as we began acting based upon our clinical observations re: shedding almost a year ago, instead of waiting for a study which may never happen to confirm it. Now I can’t count how many interviews Pierre has given on the topic!

Back to collagen. I understand that it could be upsetting to hear me assert that the supplement your functional medicine physician / chiropractor / naturopath / yoga instructor (not kidding here) recommended to you may be exacerbating coaguloptahy in your body. All you were trying to do was not look so damn old. As John Stewart recently said during his second episode of The Daily Show in nine years: “I have sinned against you. I’m sorry. It was never my intention to say out loud what I saw with my eyes and then brain. I can do better.” Instead of Stewart’s ironic statement that “democracy dies in discussion”, I could say “science dies in discussion.”

Forgive me for my habit of risk benefit analysis. Not only are there no studies supporting my position on collagen and clotting, there is even one research paper from 2004 which may contradict it. Of course that paper was written before space aliens zapped us with a bioweapon made in the distant galaxy of Wuhan and deranged our bodies to such a degree that most of our pre-exisitng lab studies, radiologic tools, and diagnostic approaches have been nearly useless. It’s also worth mentioning that the collagen market is estimated at 5.1 billion USD in 2023 and is projected to reach 7.4 Billion USD by 2030, at a compound annual growth rate (CAGR) of 5.3% from 2023 to 2030. This is a minor matter though, because I’m sure that the good people of supplement sales only have our best interests at heart. It also doesn’t really matter that there really isn’t substantial evidence to support the benefit of collagen in attaining beautiful skin, full bodied hair, strong nails. We also need not be troubled by the lack of any standardization or FDA regulation of these collagen products which are ingested in good faith by so many.

Did you know that collagen is a waste product? It’s made from the leftover connective tissue of fish, pigs and cows (unless you’re getting the vegan version). I love waste products as much as the next guy. We have had a worm composter in our basement for years. I love making them smile with a bruised avocado half. Their excrement feeds the beautiful lives of our houseplants and garden. Our cat litter is made from the refuse of lumber mills, pine wood sawdust. It smells great and we can compost it. Even yummy apple cider is a refuse product made from the seconds. The thing is that besides apple cider, I can’t think of another refuse product which I would ingest, let alone pay big money to consume.

According to historian Roxeanne Dunbar Ortiz, at its peak, the Native American population of North American reached 450 million people. They lived on this land for millenia. Uniformly, they used every part of the animals and fish which they hunted and harvested. Tendons and sinews were used to make bowstrings and thread. Cartilage and hooves could be ground into glue. But, they didn’t routinely ingest connective tissue, the basis of animal collagen. Why not? Did they intuitively understand something which escapes us in the present moment?

What follows is a case series of patients in whom I think that collagen played a role in their pathology and in most cases, may have set them up for their original injury, and often exacerbated coagulopathy. You’ll see references to Vitamin K2 as well. I won’t entertain questions about that until I’ve been able to explain my observations and strategy in next weeks’ Substack. I’ve spent a ridiculous amount of time on this project in the last week. Because the number of cases is fifteen and growing, I’m going to divide this up between today and next week. As a disclaimer, the following is for entertainment purposes only, and it is not to be misconstrued as frontline clinical insight or evidence from an expert in the field. ; )

Patient 0

18yo female x2 mRNA Pfizer vaccine injury within two weeks of second shot.  Family unvaccinated. First visit 2/23.  Previously healthy, s/p tonsillectomy, competitive athlete.  Intake reports fatigue, shortness of breath, chest pain, joint pain, dizziness when standing, fast or pounding heart rate (HR), worsened symptoms after activity. Blurred vision when exercising, dizzy, light headed, nauseous, swollen ankles, chest and back pain, heavy weight on chest, sharp pains on left side of chest, trouble breathing, high heart rate and high diastolic blood pressure when exercising. 2/23 live blood analysis showed RBC aggregates, Rouleaux formations, poikilocytes, echinocytes, schisocytes, acanthocytes, and platelet aggregation.  Initiated Aspirin, Eliquis, IVM and NAC Augmentata 3/23.  By 5/23 had seen tremendous improvement in leg movement and strength,adjusting fine motor movements, working with an unvaccinated personal trainer.  4 of 4 microclotting, severe and widespread in study 10/23.  It was surprising that her level was still this high despite five months of anticoagulation therapy.  11/23 visit revealed that several months ago she had tried collagen for 3-4 days.  During that time, leg pain and weakness which was associated with her microclotting became much worse.   Spike ab not available due to location and lack of access to a Lab Corp facility.

Batch ADRs Deaths Disabilities Life Threatening Illnesses

FN7924 No data

FM2952 2

Patient 1

20yo female, x2 mRNA Pfizer vaccine injury.  First seen 2/24.  Previously healthy with no surgical history.  Spouse is not vaccinated, and shedding exposure is primarily from her boosted mother.  Intake reports fatigue, shortness of breath, fast or pounding heart rate, possible enlarged atrium, low blood pressure.  Interview reveals strong signal of MCAS with childhood migraines and many food sensitivities. Also had pediatric GI issues which continue into the present moment.  Developed increased anxiety post-vaccine and started Lamotrigine, currently weaning.  Fainted following a competitive sports event in July 2023.   Started collagen on and off for hair/skin/bones in August 2023.   Started iron supplementation due to fatigue about December  2023.   DC’d oral birth control December 2023.  Had a second fainting episode at work in January of 2024.  Developed chest pain, dyspnea and fatigue.  ED visit showed abnormal ECG, and follow up cardiac echocardiogram was abnormal with possible atrial enlargement, further evaluation pending.  Labs for spike ab, D-dimer, neurotransmitters (urine) pending.

Patient 2

55yo female, post-acute sequelae of COVID (PASC), unvaccinated.  Spouse is vaccinated. First seen 1/24.  Hx TBI, cervical cancer, asthma, hypothyroidism S/p incarcerated inguinal hernia, hysterectomy, oophorectomy, cholecystectomy, appendectomy, tonsillectomy, adenoidectomy, right knee replacement x3 in 18 months. Intake reports fatigue, brain fog, memory problems, shortness of breath, chest pain, joint pain, dizziness when standing, symptoms worsening after activity, distant Hx of PE. Pain in the spleen, increased CRP values, inflammation, severe constipation.  COVID in late 2019, early 2020, and early November 2023.  Strong signal of MCAS,with very narrow range of foods she can eat.  Taking collagen and Vitamin K2.  Guided to DC both.

Spike ab 2345 U/mL

>>D-dimer 0.87 mg/L FEU

PAI-1 4G/4G polymorphism (denotes high risk of developing venous thromboembolism)

ADAMTS13 >100%

ADAMTS13 Ab 3 U/mL

Factor VIII Activity 70%

Serotonin, serum 76 ng/mL

Patient 3

68 year old male with PASC, unvaccinated.  Initial symptoms in 2/23 were sinus congestion, impact on right ear hearing, new diagnosis of asthma, and wet end-expiratory breath sounds.  Raynaud’s began before COVID and receiving monoclonal antibodies in the Winter of 2020.  Post-COVID, developed an arrtyhmia and worsening GERD.  Has had allergies his whole life.  Most recently, feeling well overall, but has intermittent muscular trouble with focal pain in one leg and bilateral leg fatigue after exertion.

Spike ab level: 3564 U/mL in 2/23, down to 157 U/mL 5/23, up to 2172 U/mL 12/20/23 following travel and shedding exposure. Microclotting score 3 of 4 moderate in 8/23, drop to only 2.75 of 4 in 1/24.  Question arose re: why there was such a small drop in microclotting after five months with use of Aspirin, IVM, Serrapeptase, Nattokinase, Flavay, Baobab, NAC Augmentata.  Scrutiny of medication reconciliationg (med rec) revealed that he was taking collagen protein peptides as a powder along with Vitamin K2 in an MVI.  The collagen had been recommended by a functional medicine physician for muscle soreness several years ago.  Collagen and Vitamin K2 DC’d.

Patient 4

54 y.o. female x2 mRNA Pfizer with vaccine injury.  First seen for acute COVID in 9/22.  Seen in follow up 10/22 for persistent enlarged, painful lymph nodes, then 11/22 for vaccine injury.  Had been on a proton pump inhibitor (PPI) when she was originally infected with COVID and vaccinated, which likely contributed to her injury.  She stopped this in early 11/22.  Lymph nodes in bilateral axillae continued to be painful, and she noted outbreak of Herpes Simplex Virus (HSV) lesions on her lips.  Reporting persistent heel pain, GERD.  In 12/22, had extended menses of twenty days, which stopped 4-5 days after initiation of high dose IVM.  We then dropped the dose due to emerging photosensitivity.  Nattokinase was started.  Lost weight, followed a lower histamine diet, had COVID again around Memorial Day 2023.  Menses began to be prolonged again, following acute COVID and extensive travel for work.  Was experiencing increased fatigue.  Started sipping Baobab in 7/23 as one of our twenty pilot study participants.  Spike ab level has consistently been >25,000 U/mL since first testing in 7/23, and with repeat testing in  9/23 and 1/24.  Microclotting score was 3 out of 4, moderate 8/23.

Batch ADRs Deaths Disabilities Life Threatening Illnesses

EW0177 1458 6 12 18

Fasting glucose decreased from 99 to 96 over the first month of sipping Baobab.  Menses stabilized.  Began anticoagulation with Aspirin, Eliquis and Plavix in 9/23, along with IVM, NAC Augmentata, Nattokinase.  In 10/23 saw decreased dyspnea with exertion, but injured left shoulder while lifting a heavy object. At this time she stopped taking collagen, and began taking colostrum to help heal her gut. I was not yet suspecting the role of collagen in provoking coagulopathy.  Use of the Arc Microtech helped minimize bruising and bleeding concerns on anticoagulation.  Despite stress of family health issues, job changes, and her own health challenges, she was doing well during this period.  Flavay was started in 11/23, and we fine-tuned treatment for MCAS by adding Antronex, a natural antihistamine from Standard Process.  She had an acute viral illness around Thanksgiving following exposure to many family members who were acutely ill.  We initiated peptide BPC-157 for gut healing and ProTandim for emerging cognitive concerns.  Chronic connective tissue concerns began to yield, with less shoulder and heel pain, improved appetite, resolution of skin issues.  She had backed off the Baobab use for two months.  Menses became elongated again, and she was having sleep disturbances.

Patient 5

49 yo female, PASC, unvaccinated.  Husband not vaccinated.  Hx migraines, MTHFR gene mutation, S/p ACL reconstruction.  Previous COVID-19 infection by testing or presumptive by symptoms, January 2022 and December 2022.  Onset ~ four weeks after initial COVID infection.  Intake reports brain fog, memory problems, anxiety and depression. Mother, sister’s husband and all of their close friends have been vaccinated. Was around them after sick first time. Unvaccinated daughter and son attend schools around many vaccinated students.  Husband works around many vaccinated individuals.  Shedding is an active dynamic and ongoing consideration in her care.  2/23 labs showed spike ab 844 U/mL and slight elevation of D-Dimer at 0.51 mg/L FEU, a late sign of microclotting.  3/23 labs reflected reactivation of EBV with early antigen level of 10.4 U/mL.  8/23 microclotting study showed stage/grade 4 of 4, widespread and significant.  Patient and her husband asserted that there was a mistake in the labs and this was another patient’s blood. When she went to the lab for another draw, the phlebotomist couldn’t draw her blood, because it kept clotting.  They then agreed this was in fact her blood, and wished to initiate treatment.  Started triple anticoagulation with Aspirin, Eliquis and Plavix as well as IVM, LDN, NAC Augmentata, Nattokinase.  Repeat microclotting study 11/23 showed reduction to 2.5 of 4, mild.  Patient felt 95% recovered.  In 12/23 and 1/24 visits, patient was exhibiting some relapse of symptoms secondary to shedding, but still doing well overall. In 1/24 visit she remarked, “Two weeks ago I was feeling really good.  I haven’t felt that good since 2022.”  Then her menses came, and she experienced a return of severe migraine.  At the end of the visit, in response to questioning from this provider, she reported that she had started taking collagen a few weeks ago.  Collagen DC’d after this visit. End of 2/24 patient reports that she is feeling much better, and was able to go for a one mile walk.

Patient 6

39 yo female, x2 mRNA Pfizer vaccine injury.   Increased fatigue over 2021 following vaccination.  Previous COVID-19 infection by testing or presumptive by symptoms, December 2021.    Husband vaccinated, works in health care.  Hx chronic fatigue syndrome, headaches, migraines. S/p no surgeries declared.  Intake reports fatigue, brain fog, memory problems, dizziness when standing, chest pain, tachycardia, headaches, depression or anxiety, worsened symptoms after activity, new onset daily headaches/ migraines, nausea.  One night she didn’t take her Aspirin, and the next day she had a severe headache.  “This is like dementia. I would open the fridge ten times and not knowing what I was looking for.”  During discussion late 2023, patient reported that she would use collagen supplementation in a liquid form regularly in the years before she became sick with COVID.   2/23, spike ab was 9814 U/mL.  8/23 study showed 4 of 4 microclotting, severe and widespread.  

Batch ADRs Deaths Disabilities Life Threatening Illnesses
EL0140    1243           52                    20                  24
EJ686             8

Patient 7

61yo female, PASC, unvaccinated.   First seen 4/22.  Hx of hypertension (HTN), s/p tubal ligation and foot surgery.  Three previous COVID-19 infections by testing or presumptive by symptoms, 11/2020 around Thanksgiving, and again 1/21, 7/22.  Onset 3/21, with lost of taste and smell, hypertension, fatigue, brain fog and memory problems, with worse symptoms after exertion. Stress from a busy work week also exacerbates symptoms.  Eating a low histmaine diet.  Completed BioAnalytics cytokine panel with Dr Patterson, started on Maraviroc for one month and most of symptoms resolved, although CCL4 remained elevated.  Excercise with HR > 100 provokes post-exertional malaise, and allergy symptoms with increased phlegm production and watering eyes for several days afterwards, at worst with vertigo, nausea and vomiting.  Low dose Dexamethasone was helfpul, as well as short-term, low dose Fluvoxamine.  HR improved and tapered off a beta blocker.  High dose IVM didn’t resolve loss of taste and smell; we then tried Vascepa, again without benefit.  Spike ab was 2497 U/mL.  During 2/23 visit, secondary to shedding from spouse traveling to a trade show, going to the gym, and being around vax/boosted people, saw increase in sympotm burden.  Experiencing eye twitching, vertigo, heat on back of her neck, returning fatigue, and increasing BP.  Initiated Arc Microtech after 7/23 visit.  At 11/23 visit, vertigo resolved, drop of spike ab to 940 U/mL continuing with low intensity exercise, modulating MCAS with antihistamines, and eating lower histamine diet.  Aspirin and Flavay initiated for presumed microclotting.  In successive visit Antronex and Ketotifen for MCAS initiated, and Oxytocin for taste/smell.  Completed microclotting study 1/24, which showed 2.5 of 4, mild.  During that visit, in response to my questions, she reported that she had been taking collagen 1 Tablespoon daily for years.  Collagen DC’d.  Within about two weeks of stopping the collagen, and initiating low-dose Nicotine patch, her taste and smell, which had remained elusively absent for more than two years, began to return, albeit inconsistently.  

P.S.. Thank you to Dr Ronald Epner for your generous financial support as the first reader to become a Founder. And thank you to each of the individuals who has chosen to support this work by becoming paid subscribers.

P.S.S. If you know someone in Wyoming or West Virginia who would enjoy reading Lightning Bug, please share. Those are the only two states from which I don’t have subscribers. I’m offering a free lifetime subscription to the first person from each of those states to become a reader.

P.S.S.S. I tried to send out a brief survey re: collagen and it didn’t work out of the box, so I deleted it. I’ll try again after learning more about this tool.

PAST

When I was in seventh grade, we moved to the sticks. Our home was across the road from a state game preserve, which was literally swamplands. We had no cable, and the primary source of heat was a big woodstove to which I dedicated many hours, stacking wood, carrying wood inside, starting fires in the morning, and keeping the fire burning during the day. The bus stop after school was a quarter mile from our house down a gravel and oil road. We didn’t have Atari and my parents worked. There was only so much trouble to get into.

The single TV channel we could get carried The Rockford Files with James Garner, and so my slacker afterschool routine was to grab a big mug of Lipton instant tea, a bag of pretzels, and plop down on the worn sofa by the wood stove to watch. I’m really not sure it’s fair to call the sugary mixture tea, as it bears so little resemblance to the real stuff. But I loved the salty sweet yeasty flavors of fake tea and pretzels, and couldn’t get enough of Jim Rockford’s misadventures.

Years before the handsome Tom Selleck played Magnum PI, James Garner won my heart. Magmum PI lived the cushy life in a Hawaiian guest house and rolled in a red Ferrari. Rockford was the cranky antihero who drove 1974-1978 model year Pontiac Firebirds, was a wrongly convicted ex-con, and lived with his dad Rocky in a trailer. He got beat up more often than not.

My favorite scene ever was when Rockford flipped his cigarette into the face of a thug. It was supposed to be a distraction, enabling him to land a punch and escape. Instead, the thug didn’t miss a beat and knocked Rockford off his block. It’s not that I liked seeing my guy get beat up. It’s more that I felt validated, like, “Yeah, you think you’ve got it figured out and it never goes the way you imagined. Blam!”

RECENT PAST

My Nana took tea to the next level. She would brew half a dozen bags of Lipton orange pekoe tea for-ev-er on the stovetop in a gallon pot whose sole duty was tea time. Then she would dump a little can of frozen lemonade in and voila! Iced tea Marsland-style.

In my late twenties I would make fun of my friend Brett and his tea habits. He wouldn’t be caught drinking tea made with a tea bag. In his cupboard were special decorative cans from Kusmi Tea with names like Prince Vladmir. He had a special tea pot which heated water to just the right temperature for a particular tea, AND he had a timer to brew it for a specified time. It all seemed so precious and pretentious, and I figured, well, unless you were English or a metrosexual, a bag of Lipton was adequate.

Fast forward twenty five years and I think that Brett could make fun of me! In the top drawer of my work desk I have a thermometer and a tea strainer. Teabag tea tastes like cardboard to me now, and there is a time and a temperture for all: two minutes for Sencha, three for green, four for black, and five for Pu’er. 160F for green, 170F for Matcha (and a whisk don’t you know), boiling hot for black. And no burned tongue for me, as it won’t pass my lips until it’s cooled to 140F. Rishi Tea, the largest American importer of organic teas became my go-to supplier.

With the pandemic, green tea went beyond yumminess to essential equipment for survival. I was working evenings at SUNY Upstate in the trauma center, and the drive home at 12:30am was 1 1/2 hours of bleak, cold, darkness. I calculated that I could start sipping upon departure and stay awake on the road, then drink a big glass of water upon arrival home and wash out the caffeine. It wasn’t until I joined Pierre at The Leading Edge Clinic and began learning how to fight COVID, then treat post-acute sequelae of COVID (PASC) and vaccine injury that I realized how important that green tea had been.

There are multiple studies now which demonstrate how the epigallocatechin gallate (EGCG) in green tea blocks spike entry into cells. See studies here, there and everywhere. It turns out that after spending hours providing bedside care to sweating, coughing, distressed acute COVID patients, that green tea was not only keeping me awake on the drive home, it was also blocking spike from taking hold in my body.

PRESENT

All Along the Watchtower by Bob Dylan, made famous by Jimi Hendrix:

There must be some kind of way outta here
Said the joker to the thief
There’s too much confusion
I can’t get no relief

Business men, they drink my wine
Plowmen dig my earth
None will level on the line
Nobody offered his word
Hey, hey

No reason to get excited
The thief, he kindly spoke
There are many here among us
Who feel that life is but a joke
But, uh, but you and I, we’ve been through that
And this is not our fate
So let us stop talkin’ falsely now
The hour’s getting late, hey

If you’ve read this far, let me reward your curiosity and tenacity by introducing you to Baobab. After eight months of personal and patients’ use, tracking labs and monitoring clinical effect, I think it is some kind of way out of the confusion, and none too soon.

Baobab is a tree which covers half the continent of Africa. It dates back to biblical times, and was important to tribal people in arid desert regions, because both its hollow core and spongy bark could store water. It is an odd looking tree, which produces a large fruit the size of a football, which has a hard shell. When ripe, the fruit is a dry powder which can be mechanically separated from fiber and seeds. Every single part of the tree is useful to humans and animals alike. The leaves can provide forage for wild animals and livestock, the bark can be made into rope, the wood used for fuel, and the fruit for medicinal purposes. For these reasons it is often referred to as The Tree of Life.

Before there were words for these actions, Baobab fruit was antibiotic, antiviral, antifungal, antipyretic (fever lowering), and poison neutralizing. Tribespeople who hunt with poison tipped arrows and spears will mix Baobab powder with water to apply to the entry wound and neutralize the poison so that they can eat the flesh. Baobob has a pre-biotic fiber which modulates glucose metabolism, thus lowering fasting blood glucose levels. The fiber also creates a welcoming environment for an abundant and diverse population of bifida bacteria in the gut.

Baobab also has EGCG.

Last Spring, Pierre was at a conference in Hawaii and I was covering some of his patients. It was serendipity that I saw the labs come back for a family which had decided to measure the spike antibody for everyone in the household. Mom, college-age daughter and high school-age daughter were unvaccinated, with spike antibody (ab) levels of ~7,000, 3500 and 1500 U/mL respectively. Dad is a physician working in a busy outpatient clinic. He received two Pfizer shots, both from bad batches, and was exposed to ongoing shedding while delivering patient care in a healthcare environment. His spike ab was about 100 U/mL. I was stunned, and understood that this was either a lab error or a very intriguing aberration.

I picked up the phone and called this family, speaking with the mom at length. Dad didn’t take any medications, nor did he take any supplements. In fact, it took about thirty minutes to uncover what he could possibly be doing which would result in such a low spike ab level. Finally she said, “Well, there is this drink he makes every morning and takes to work. It has Baobab powder, and he mixes it with stevia and ginger. He only drinks it during the week, and sips it over the course of the day.” Why Baobab I asked? “It has a lot of vitamin C, and pre-biotics, but I’m not really sure. He’s been drinking it for years.” I thanked her and hung up, then spent the next four hours reading papers about Baobab.

As I read about Baobab’s many qualities, and then learned that it had EGCG, I concluded that the Baobab was somehow connected to this physician’s low spike ab level. He was patient 0. Researchers had considered Baobab to control COVID, but as far as I could tell, hadn’t pursued it further. I pulled $500 out of my piggy bank, messaged twenty patients whose spike ab levels were >25,000 U/mL or relatively high, and made them a proposal. Eat, drink, sip, but one way or the other get 1 Tbsp of Baobab in your body every day for a month, and then let’s recheck your spike ab level.

Within the month the feedback started to roll in, and I had my own experience to contribute. I started drinking the Baobab with my morning vitamins. That didn’t go so well, because I ended up with increased paresthesias (decreased sensation) in my toes and feet. After hearing the same story from three other participants in the pilot study, I suggested that we all sip it over the course of the day, like patient 0. The paresthesias resolved.

When the spike ab results started to come back after a month of Baobab, there was a signal. If patients ate it or drank it, there was a slight change in their levels. But if they sipped it, boy howdy! There were drops in spike ab levels reaching 5,000 U/mL over a month. That was enough for me, and I began guiding patients to sip Baobab, 1 Tbsp in 16oz of water over at least an eight hour period.

More feedback with additional patients revealed a few quirks of the therapy. If someone has severe mast cell activation syndrome (MCAS), they may need to go low and slow. Well, just about all of our patients have some level of mast cell activation, so I guided everyone to start with adding only 1/4 teaspoon to 16oz of water and slowly advancing. Initially, some patients (including me) experienced some bloating while sipping Baobab. I’ll attribute this to the recalibration of our microbiomes as we build up the bifida.

Labs in patients who were sipping Baobab showed a declining fasting glucose, similar to what we see when we use Berberine. Patients also report enormous formed brown stools with a clean finish, i.e. no wiping necessary, and a sensation of complete bowel evacuation. Gotta love that.

Then things got interesting. We have been treating patients for microclotting for over a year now, and so some patients were beginning to retest. What I saw was multiple signals that unvaccinated PASC patients who were sipping Baobab dropped their microclotting scores by two points in 2-3 months. For reference, it often takes six months on anticoagulation with Aspirin, Eliquis and Plavix for a PASC or vaccine injured patient to drop his/her/their score one point. It would appear that not only does Baobab block spike entry into cells, but also that it helps break down microclots faster and safely. How?

The likely answer arrived a few weeks ago when I was reading a review article about natural products for antithrombosis. I learned that EGCG acts along the COX-1 pathway, same as Aspirin, to inhibit platelet aggregation and activation. Whereas Aspirin has about a 20% effect, EGCG has about a 90% effect.

Why not just take EGCG then? Well, you could. But any herbalist worth his/her/their salt would explain that when you isolate an active component of a plant-based remedy, you leave behind other components which synergize and ameliorate adverse effects. Given what I have seen clinically over the last eight months, my vote is to stick with green tea and Baobab sipping.

Where do you get Baobab? There are plenty of sources online if you want to shop around, as Baobab is an agricultural product.

How do you mix it? If you can make gravy without lumps, you can mix Baobab. I usually start the day by slowly tapping one Tbsp of Baobab into a cup of water as I stir it with a spoon. I smush out any remaining lumps, and then add this to a thermos with cold water, shaking and sipping every half hour over the course of the day. Every time I talk to a patient about Baobab, I take a sip!

What does it taste like? I would describe Baobab as having a mild citrus flavor. If it doesn’t agree with you, feel free to flavor it like patient 0. A few patients have complained that it has given them heartburn, and there have been others who can’t be bothered with the fuss and muss of mixing/sipping. My position it this: Baobab costs about $20 for a 1 1/2 month supply, blocks spike, breaks down microclots, builds up my bifida, lowers my fasting glucose, doesn’t taste too bad, and helps me have a very satisfying poop every day. Sold!

Baobab sipping is an economical way to combat shedding. My suggestion is to prepare your Baobab sipper before you head into any social interaction. Start sipping ahead of time, sip during the event, and continue sipping afterwards. In effect you are delivering a steady supply of EGCG and whatever synergy we haven’t yet isolated in a lab, which is blocking spike entry into your cells. If you are going to travel, bring the powder with you and once you are through airport security, mix it up at the water fountain and get down to sipping. Our patients and team have been doing this for months, and overall the results have been positive.

Cheers!

P.S. If you have ever seen a Guardians of the Galaxy movie, you can appreciate the power of a groovy soundtrack. My wife and I really enjoyed the updated series of Battlestar Galactica, and I’ll never forget when Jimi Hendrix’s anthem showed up in the narrative. Five main characters keep hearing the song in their head, and end up together in the same rom where they realize they are the Final Five Cylons. Internet wisdom says: “The song’s biblical and mythical connections make it fitting for the show, as it foreshadows destruction and leads to a new world.”

P.S.S. I have no financial stake in any of the products I recommend, including Rishi Tea.